Exposures influencing total IgA level in colostrum

Immunoglobulin A (IgA) is a predominant immunoglobulin present in human breast milk and is known to play an important role in infant gut immunity maturation. Breast milk composition varies between populations, but the environmental and maternal factors responsible for these variations are still uncl...

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Bibliographic Details
Published in:Journal of developmental origins of health and disease 2016-02, Vol.7 (1), p.61-67
Main Authors: Munblit, D., Sheth, S., Abrol, P., Treneva, M., Peroni, D. G., Chow, L.-Y., Boner, A. L., Pampura, A., Warner, J. O., Boyle, R. J.
Format: Article
Language:English
Subjects:
Adult
Allergies
Babies
Baby foods
Breastfeeding & lactation
Cohort Studies
Colostrum - chemistry
Colostrum - immunology
Cytokines
Diet
Ethics
Female
Growth factors
Humans
Hypersensitivity - immunology
Immunoglobulin A - analysis
Immunoglobulins
Immunology
Labor, Obstetric - immunology
Milk
Mothers
Original Article
Parity - immunology
Pregnancy
Pregnancy Complications - immunology
Probiotics
R&D
Research & development
Smoking
Statistical analysis
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Summary:Immunoglobulin A (IgA) is a predominant immunoglobulin present in human breast milk and is known to play an important role in infant gut immunity maturation. Breast milk composition varies between populations, but the environmental and maternal factors responsible for these variations are still unclear. We examined the relationship between different exposures and levels of IgA in colostrum. The objective of this study was to examine whether exposures analysed influence levels of IgA in colostrum. The present study used 294 colostrum samples from the MecMilk International cohort, collected from women residing in London, Moscow and Verona. Samples were analysed in automated Abbott Architect Analyser. We found an inverse correlation between time postpartum and colostrum total IgA level (r=−0.49, P
ISSN:2040-1744
2040-1752
DOI:10.1017/S2040174415001476