Carcinogenicity of fluoro-edenite, silicon carbide fibres and whiskers, and carbon nanotubes

Occupational exposures associated with the Acheson process were classified as carcinogenic to humans (Group 1) on the basis of sufficient evidence in humans that they cause lung cancer. Since the correlation between exposures to SiC fibres and cristobalite made it difficult to disentangle their inde...

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Published in:The lancet oncology 2014-12, Vol.15 (13), p.1427-1428
Main Authors: Grosse, Yann, Loomis, Dana, Guyton, Kathryn Z, Lauby-Secretan, Béatrice, El Ghissassi, Fatiha, Bouvard, Véronique, Benbrahim-Tallaa, Lamia, Guha, Neela, Scoccianti, Chiara, Mattock, Heidi, Straif, Kurt
Format: Article
Language:English
Subjects:
Asbestos, Amphibole - adverse effects
Biocompatible Materials - adverse effects
Carbon
Carbon Compounds, Inorganic - adverse effects
Carcinogens
Cell Transformation, Neoplastic - chemically induced
Cell Transformation, Neoplastic - pathology
Composite materials
Hematology, Oncology and Palliative Medicine
Herbicides
Humans
Insecticides
Nanotubes, Carbon - adverse effects
Neoplasms - chemically induced
Neoplasms - pathology
Rodents
Silicon Compounds - adverse effects
Studies
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Summary:Occupational exposures associated with the Acheson process were classified as carcinogenic to humans (Group 1) on the basis of sufficient evidence in humans that they cause lung cancer. Since the correlation between exposures to SiC fibres and cristobalite made it difficult to disentangle their independent effects, the Working Group concluded that fibrous SiC is possibly carcinogenic to humans (Group 2B) based on limited evidence in humans that it causes lung cancer. Furthermore, the lack of coherent evidence across the various distinct CNTs precluded generalisation to other types of CNTs. [...]MWCNT-7 was classified as possibly carcinogenic to humans (Group 2B); and SWCNTs and MWCNTs excluding MWCNT-7 were categorised as not classifiable as to their carcinogenicity to humans (Group 3).
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(14)71109-X