Influence of 516G>T Polymorphisms at the Gene Encoding the CYP450-2B6 Isoenzyme on Efavirenz Plasma Concentrations in HIV-Infected Subjects

We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus–" ALIGN="BASELINE">positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous...

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Published in:Clinical infectious diseases 2005-05, Vol.40 (9), p.1358-1361
Main Authors: Rodriguez-Novoa, Sonia, Barreiro, Pablo, Rendón, Ana, Jiménez-Nacher, Inmaculada, González-Lahoz, Juan, Soriano, Vincent
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretrovirals
Antiviral agents
Antivirals
Benzoxazines
Biological and medical sciences
Cytochrome P-450 Enzyme System - genetics
Cytochromes
Drug therapy
Female
Genes
Genomics
Genotype
Genotype & phenotype
Genotypes
Heterozygote
HIV
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - genetics
HIV/AIDS
Homozygote
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Isoenzymes - genetics
Liver
Male
Medical sciences
Medical treatment
Medical treatment failures
Metabolism
Middle Aged
Oxazines - adverse effects
Oxazines - blood
Oxazines - pharmacokinetics
Pharmacokinetics
Pharmacology. Drug treatments
Plasma
Polymorphism, Single Nucleotide
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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creator Rodriguez-Novoa, Sonia
Barreiro, Pablo
Rendón, Ana
Jiménez-Nacher, Inmaculada
González-Lahoz, Juan
Soriano, Vincent
description We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus–" ALIGN="BASELINE">positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.
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Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.</description><identifier>ISSN: 1058-4838</identifier><identifier>EISSN: 1537-6591</identifier><identifier>DOI: 10.1086/429327</identifier><identifier>PMID: 15825040</identifier><identifier>CODEN: CIDIEL</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiretrovirals ; Antiviral agents ; Antivirals ; Benzoxazines ; Biological and medical sciences ; Cytochrome P-450 Enzyme System - genetics ; Cytochromes ; Drug therapy ; Female ; Genes ; Genomics ; Genotype ; Genotype &amp; phenotype ; Genotypes ; Heterozygote ; HIV ; HIV Infections - blood ; HIV Infections - drug therapy ; HIV Infections - genetics ; HIV/AIDS ; Homozygote ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Isoenzymes - genetics ; Liver ; Male ; Medical sciences ; Medical treatment ; Medical treatment failures ; Metabolism ; Middle Aged ; Oxazines - adverse effects ; Oxazines - blood ; Oxazines - pharmacokinetics ; Pharmacokinetics ; Pharmacology. Drug treatments ; Plasma ; Polymorphism, Single Nucleotide ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.</description><subject>Adult</subject><subject>Antibiotics. Antiinfectious agents. 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source Oxford Academic Journals (OUP); JSTOR
subjects Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretrovirals
Antiviral agents
Antivirals
Benzoxazines
Biological and medical sciences
Cytochrome P-450 Enzyme System - genetics
Cytochromes
Drug therapy
Female
Genes
Genomics
Genotype
Genotype & phenotype
Genotypes
Heterozygote
HIV
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - genetics
HIV/AIDS
Homozygote
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Isoenzymes - genetics
Liver
Male
Medical sciences
Medical treatment
Medical treatment failures
Metabolism
Middle Aged
Oxazines - adverse effects
Oxazines - blood
Oxazines - pharmacokinetics
Pharmacokinetics
Pharmacology. Drug treatments
Plasma
Polymorphism, Single Nucleotide
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
title Influence of 516G>T Polymorphisms at the Gene Encoding the CYP450-2B6 Isoenzyme on Efavirenz Plasma Concentrations in HIV-Infected Subjects
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