Influence of 516G>T Polymorphisms at the Gene Encoding the CYP450-2B6 Isoenzyme on Efavirenz Plasma Concentrations in HIV-Infected Subjects

We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus–" ALIGN="BASELINE">positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous...

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Bibliographic Details
Published in:Clinical infectious diseases 2005-05, Vol.40 (9), p.1358-1361
Main Authors: Rodriguez-Novoa, Sonia, Barreiro, Pablo, Rendón, Ana, Jiménez-Nacher, Inmaculada, González-Lahoz, Juan, Soriano, Vincent
Format: Article
Language:English
Subjects:
Adult
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretrovirals
Antiviral agents
Antivirals
Benzoxazines
Biological and medical sciences
Cytochrome P-450 Enzyme System - genetics
Cytochromes
Drug therapy
Female
Genes
Genomics
Genotype
Genotype & phenotype
Genotypes
Heterozygote
HIV
HIV Infections - blood
HIV Infections - drug therapy
HIV Infections - genetics
HIV/AIDS
Homozygote
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Isoenzymes - genetics
Liver
Male
Medical sciences
Medical treatment
Medical treatment failures
Metabolism
Middle Aged
Oxazines - adverse effects
Oxazines - blood
Oxazines - pharmacokinetics
Pharmacokinetics
Pharmacology. Drug treatments
Plasma
Polymorphism, Single Nucleotide
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Description
Summary:We examined 516G>T polymorphisms at the gene encoding the cytochrome P450 in 100 human immunodeficiency virus–" ALIGN="BASELINE">positive subjects who were receiving efavirenz (EFV). Elevated plasma EFV concentrations were found in 40% of subjects with the polymorphic homozygous genotype and 19% of subjects with the heterozygous genotype. Conversely, 20% of subjects with the wild-type genotype had subtherapeutic concentrations of EFV. CYP2B6-516 genotyping may help to identify subjects who have plasma EFV concentrations that are outside of the therapeutic range.
ISSN:1058-4838
1537-6591
DOI:10.1086/429327