Paraoxanase as an indicator of myocardial ischemia and its utility in determining extension of ischemia

Abstract Background The aim of this study was to investigate Paraoxanase 1 (PON-1) activity in patients with ST-elevated and non–ST-elevated acute myocardial infarction (AMI) and to determine its correlation with Gensini scores (GSs). Methods A total of 109 patients with AMI and 58 healthy subjects...

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Published in:The American journal of emergency medicine 2016-01, Vol.34 (1), p.45-48
Main Authors: Erenler, Ali Kemal, MD, Kocabaş, Ramazan, MD, Doğan, Tolga, MD, Erdemli, Hacı Kemal, MD, Yetim, Mücahit, MD
Format: Article
Language:English
Subjects:
Age
Aged
Aryldialkylphosphatase - blood
Atherosclerosis
Biomarkers - blood
Body mass index
Cardiovascular disease
Cholesterol
Coronary Angiography
Coronary vessels
Emergency
Emergency medical care
Emergency Service, Hospital
Family medical history
Female
Females
Glucose
Heart attacks
Humans
Hypertension
Ischemia
Laboratories
Male
Middle Aged
Myocardial Ischemia - diagnosis
Myocardial Ischemia - diagnostic imaging
Myocardial Ischemia - enzymology
Regression analysis
Severity of Illness Index
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Summary:Abstract Background The aim of this study was to investigate Paraoxanase 1 (PON-1) activity in patients with ST-elevated and non–ST-elevated acute myocardial infarction (AMI) and to determine its correlation with Gensini scores (GSs). Methods A total of 109 patients with AMI and 58 healthy subjects as control group were included in the study. Patients were divided into 2 subgroups as ST-elevated and non–ST-elevated AMI patients (Group I and II, respectively). Controls were named as Group III. PON-1 activity was determined on admission to emergency department for each group. In addition, GSs for patient groups were determined. Then, groups were compared according to their results. Results PON-1 levels in Group I and II were significantly lower when compared to Group III. Median GSs for Group I and II were 60 and 64, respectively. The cut-off value of PON-1 for diagnosis of AMI was ≤ 180 U/L, which was identified by receiver characteristics receiver curve analysis. However, we could not determine a significant relationship between serum PON-1 levels and GSs in patients with AMI. Conclusion PON-1 levels measured on admission to emergency department may be used to rule out AMI. PON-1 levels in AMI patients are found to be inefficient in determining extension of ischemia measured by GS.
ISSN:0735-6757
1532-8171
DOI:10.1016/j.ajem.2015.09.008