Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools

Abstract Background Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments t...

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Bibliographic Details
Published in:Journal of affective disorders 2016-01, Vol.190, p.607-615
Main Authors: Ott, Caroline Vintergaard, Bjertrup, Anne Juul, Jensen, Johan Høy, Ullum, Henrik, Sjælland, René, Purdon, Scot E, Vieta, Eduard, Kessing, Lars V, Miskowiak, Kamilla W
Format: Article
Language:English
Subjects:
Adult
Assessment
Case-Control Studies
Cognition
Cognition Disorders - complications
Cognition Disorders - diagnosis
Depression
Depressive Disorder - complications
Depressive Disorder - psychology
Female
Humans
Male
Mood disorder
Neuropsychological Tests
Psychiatry
Reproducibility of Results
Screening
Self-Assessment
Sensitivity and Specificity
Socio-occupational function
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Summary:Abstract Background Persistent cognitive dysfunction in unipolar depression (UD) contributes to socio-occupational impairment, but there are no feasible methods to screen for and monitor cognitive dysfunction in this patient group. The present study investigated the validity of two new instruments to screen for cognitive dysfunction in UD, and their associations with socio-occupational capacity. Method Participants ( n =53) with UD in partial or full remission and healthy control persons ( n =103) were assessed with two new screening instruments, the Danish translations of the Screen for Cognitive Impairment in Psychiatry (SCIP-D) and Cognitive Complaints in Bipolar Disorder Rating Assessment (COBRA) and with established neuropsychological and self-assessment measures. Depression symptoms and socio-occupational function were rated with the Hamilton Depression Rating Scale and Functional Assessment Short Test respectively. Results The SCIP-D and COBRA were valid for detection of objective and subjective cognitive impairment, respectively. The three parallel SCIP-D forms were equivalent. A combined SCIP-D-COBRA measure showed high sensitivity and good specificity for objective cognitive impairment (91% and 70%, respectively). There was no correlation between subjective and objective measures of cognition. Subjective cognitive difficulties correlated more with socio-occupational impairment ( r =0.7, p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2015.10.059