The MCCB impairment profile in a Spanish sample of patients with schizophrenia: Effects of diagnosis, age, and gender on cognitive functioning

AbstractThe MATRICS Consensus Cognitive Battery (MCCB) was administered to 293 schizophrenia outpatients and 210 community residents in Spain. Our first objective was to identify the age- and gender-corrected MCCB cognitive profile of patients with schizophrenia. The profile of schizophrenia patient...

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Bibliographic Details
Published in:Schizophrenia research 2015-12, Vol.169 (1), p.116-120
Main Authors: Rodriguez-Jimenez, R, Dompablo, M, Bagney, A, Santabárbara, J, Aparicio, A.I, Torio, I, Moreno-Ortega, M, Lopez-Anton, R, Lobo, A, Kern, R.S, Green, M.F, Jimenez-Arriero, M.A, Santos, J.L, Nuechterlein, K.H, Palomo, T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Aging - psychology
Cognition
Cross-Sectional Studies
Gender
Humans
MATRICS
MCCB
Middle Aged
Neuropsychological Tests
Psychiatric/Mental Health
Schizophrenia
Schizophrenia - diagnosis
Schizophrenia - epidemiology
Schizophrenic Psychology
Sex Characteristics
Spain - epidemiology
Young Adult
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Summary:AbstractThe MATRICS Consensus Cognitive Battery (MCCB) was administered to 293 schizophrenia outpatients and 210 community residents in Spain. Our first objective was to identify the age- and gender-corrected MCCB cognitive profile of patients with schizophrenia. The profile of schizophrenia patients showed deficits when compared to controls across the seven MCCB domains. Reasoning and Problem Solving and Social Cognition were the least impaired, while Visual Learning and Verbal Learning showed the greatest deficits. Our second objective was to study the effects on cognitive functioning of age and gender, in addition to diagnosis. Diagnosis was found to have the greatest effect on cognition (Cohen's d > 0.8 for all MCCB domains); age and gender also had effects on cognitive functioning, although to a lesser degree (with age usually having slightly larger effects than gender). The effects of age were apparent in all domains (with better performance in younger subjects), except for Social Cognition. Gender had effects on Attention/Vigilance, Working Memory, Reasoning and Problem Solving (better performance in males), and Social Cognition (better performance in females). No interaction effects were found between diagnosis and age, or between diagnosis and gender. This lack of interactions suggests that age and gender effects are not different in patients and controls.
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2015.09.013