Bioengineering functional copolymers: V. Synthesis, LCST, and thermal behavior of poly(N-isopropyl acrylamide-co-p-vinylphenylboronic acid)

New boron‐containing stimuli‐responsive (pH‐ and temperature‐sensitive) copolymers were synthesized and characterized. Structure and composition of copolymers were determined by FTIR and 1H‐NMR spectroscopy, and elemental analysis and titration (N and B contents for NIPA and VPBA unit, respectively)...

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Bibliographic Details
Published in:Journal of applied polymer science 2005-02, Vol.95 (3), p.573-582
Main Authors: Çimen, E. K., Rzaev, Zakir M. O., Pişkin, E.
Format: Article
Language:English
Subjects:
Applied sciences
copolymerization
Exact sciences and technology
N-isopropylacrylamide
Organic polymers
p-vinylphenylboronic acid
Physicochemistry of polymers
Polymers with particular properties
Preparation, kinetics, thermodynamics, mechanism and catalysts
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Summary:New boron‐containing stimuli‐responsive (pH‐ and temperature‐sensitive) copolymers were synthesized and characterized. Structure and composition of copolymers were determined by FTIR and 1H‐NMR spectroscopy, and elemental analysis and titration (N and B contents for NIPA and VPBA unit, respectively). By DSC and XRD measurements, it is established that the synthesized copolymers have a semicrystalline structure due to formation of intra‐ and/or intermolecular H‐bonded supramolecular architecture. The copolymer composition–structure–property relationship indicates semicrystalline structure of copolymers with different compositions, degrees of crystallinity, and thermal and stimuli‐responsive behaviors depends on the content of boron‐containing monomer linkage. Results of DSC, DTA, and TGA analyses indicated that copolymers have Tg and Tm and high thermal stability. These water‐soluble and temperature‐ and pH‐sensitive amphiphilic copolymers can be used as polymeric carries for delivery of biological entities for diverse biomedical use, including boron neutron capture therapy. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 95: 573–582, 2005
ISSN:0021-8995
1097-4628
DOI:10.1002/app.21260