A roadmap for precision medicine in the epilepsies

Summary Technological advances have paved the way for accelerated genomic discovery and are bringing precision medicine clearly into view. Epilepsy research in particular is well suited to serve as a model for the development and deployment of targeted therapeutics in precision medicine because of t...

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Bibliographic Details
Published in:Lancet neurology 2015-12, Vol.14 (12), p.1219-1228
Main Author: Anon
Format: Article
Language:English
Subjects:
Anticonvulsants - therapeutic use
Clinical trials
Disease
Drug Discovery
Epilepsy
Epilepsy - drug therapy
Epilepsy - genetics
Fees & charges
Genes
Genetics
Genomes
Health risk assessment
Humans
Inventors
Licenses
Medicine
Meetings
Mutation
Neurology
Precision Medicine
Studies
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Summary:Summary Technological advances have paved the way for accelerated genomic discovery and are bringing precision medicine clearly into view. Epilepsy research in particular is well suited to serve as a model for the development and deployment of targeted therapeutics in precision medicine because of the rapidly expanding genetic knowledge base in epilepsy, the availability of good in-vitro and in-vivo model systems to efficiently study the biological consequences of genetic mutations, the ability to turn these models into effective drug-screening platforms, and the establishment of collaborative research groups. Moving forward, it is crucial that these collaborations are strengthened, particularly through integrated research platforms, to provide robust analyses both for accurate personal genome analysis and gene and drug discovery. Similarly, the implementation of clinical trial networks will allow the expansion of patient sample populations with genetically defined epilepsy so that drug discovery can be translated into clinical practice.
ISSN:1474-4422
1474-4465
DOI:10.1016/S1474-4422(15)00199-4