Dissociable cerebellar activity during spatial navigation and visual memory in bilateral vestibular failure

Highlights • Spatial orientation and navigation depends on information from the vestibular system. • In this study, patients with bilateral vestibular failure did not differ in navigational performance from controls. • Groups did not differ in navigation-related activity in the hippocampus. • Patien...

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Bibliographic Details
Published in:Neuroscience 2015-10, Vol.305, p.257-267
Main Authors: Jandl, N.M, Sprenger, A, Wojak, J.F, Göttlich, M, Münte, T.F, Krämer, U.M, Helmchen, C
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
bilateral vestibular failure
Brain Mapping
Case-Control Studies
cerebellum
Cerebellum - blood supply
Cerebellum - physiopathology
Female
Humans
Image Processing, Computer-Assisted
Magnetic Resonance Imaging
Male
Memory - physiology
Middle Aged
navigation
Neurology
Oxygen - blood
Photic Stimulation
Psychophysics
Space Perception
Spatial Navigation - physiology
Vestibular Diseases - pathology
Vestibular Diseases - physiopathology
Vestibular Evoked Myogenic Potentials - physiology
visual memory
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Summary:Highlights • Spatial orientation and navigation depends on information from the vestibular system. • In this study, patients with bilateral vestibular failure did not differ in navigational performance from controls. • Groups did not differ in navigation-related activity in the hippocampus. • Patients showed higher cerebellar activity during spatial navigation than during visual memory tasks. • Cerebellar activity may be related to a change in navigational (from allocentric to sequence-based) strategy.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.07.089