Adolescent nicotine exposure fails to impact cocaine reward, aversion and self-administration in adult male rats

The present experiments examined the effects of adolescent nicotine pre-exposure on the rewarding and aversive effects of cocaine and on cocaine self-administration in adult male rats. In Experiment 1, adolescent Sprague–Dawley rats (postnatal days 28–43) were given once daily injections of nicotine...

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Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2015-10, Vol.137, p.30-37
Main Authors: Pomfrey, Rebecca L., Bostwick, Tamaara A., Wetzell, B. Bradley, Riley, Anthony L.
Format: Article
Language:English
Subjects:
Adolescent drug exposure
Age Factors
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Cocaine - administration & dosage
Cocaine self-administration
Conditioned place preference
Conditioned taste avoidance
Dose-Response Relationship, Drug
Male
Nicotine - administration & dosage
Nicotine pre-exposure
Rats
Rats, Sprague-Dawley
Reward
Self Administration
Sprague–Dawley rats
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Summary:The present experiments examined the effects of adolescent nicotine pre-exposure on the rewarding and aversive effects of cocaine and on cocaine self-administration in adult male rats. In Experiment 1, adolescent Sprague–Dawley rats (postnatal days 28–43) were given once daily injections of nicotine (0.6mg/kg) or vehicle and then tested for the aversive and rewarding effects of cocaine in a combined conditioned taste avoidance (CTA)/conditioned place preference (CPP) procedure in adulthood. In Experiment 2, adolescent Sprague–Dawley rats were pre-exposed to nicotine then tested for cocaine self-administration (0.25 or 0.75mg/kg), progressive ratio (PR) responding, extinction and cue-induced reinstatement in adulthood. In Experiment 1, rats showed significant dose-dependent cocaine-induced taste avoidance with cocaine-injected subjects consuming less saccharin over trials, but no effect of nicotine pre-exposure. For place preferences, cocaine induced significant place preferences with cocaine injected subjects spending significantly more time on the cocaine-paired side, but again there was no effect of nicotine history. All rats in Experiment 2 showed clear, dose-dependent responding during cocaine acquisition, PR testing, extinction and reinstatement with no effect of nicotine pre-exposure. These studies demonstrate that adolescent nicotine pre-exposure does not have an impact on cocaine's affective properties or its self-administration at least with the specific parametric conditions under which these effects were tested. •Nicotine pre-exposure resulted in weight and locomotor differences.•Adolescent nicotine exposure did not affect cocaine intake during adulthood.•Cocaine induced adult, dose-dependent taste avoidance, regardless of pre-exposure.•Cocaine induced adult place preferences with no effects of nicotine pre-exposure.•Rats had clear dose dependent self-administration, with no nicotine pre-exposure effects.
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2015.08.004