Phytochemical investigation and in vitro antinociceptive activity of Clerodendrum indicum leaves

The crude ethanolic extracts of Clerodendrum indicum Linn. leaves were investigated for possible antinociceptive activity using acetic acid induced writhing model in mice. Phytochemical analysis was also carried out according to the standard procedures to identify the presence of different phytocons...

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Bibliographic Details
Published in:Pakistan journal of biological sciences 2012-02, Vol.15 (3), p.152-155
Main Authors: Raihan, Sheikh Zahir, Biswas, Pranoyjit, Monir, Md Moniruzzaman, Biswas, Subrata Kumar, Chowdhury, Anusua, Rahman, A K M Shahidur
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Analgesics - pharmacology
Animals
Clerodendrum - metabolism
Clerodendrum indicum
Ethanol - chemistry
Female
Male
Mice
Models, Statistical
Phytotherapy - methods
Plant Extracts - pharmacology
Plant Leaves - metabolism
Reproducibility of Results
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Summary:The crude ethanolic extracts of Clerodendrum indicum Linn. leaves were investigated for possible antinociceptive activity using acetic acid induced writhing model in mice. Phytochemical analysis was also carried out according to the standard procedures to identify the presence of different phytoconstituents in the ethanolic extract of the plant leaves. The study results showed 38.91 and 55.24% inhibition of writhings in the tested mice when ethanolic extract of Clerodendrum indicum Linn. leaves at doses of 250 and 500 mg kg(-1) body weight was given intraperitoneally, respectively. The study results were also compared with antinociceptive activity of the standard drug, Diclofenac sodium (68.37% inhibition) used at 25 mg kg(-1) body weight. At the above doses, the crude ethanolic extract of the plant showed significant antinociceptive activity in dose dependent fashion in acetic acid-induced writhing model in mice. The inhibition of writhings was calculated in respective to control group and it was found that p-values (
ISSN:1028-8880
1812-5735
DOI:10.3923/pjbs.2012.152.155