Front propagation speeds of T7 virus mutants

We propose a new reaction–diffusion model with an eclipse time to study the spread of viruses on bacterial populations. This new model is both biologically and physically sound, unlike previous ones. We determine important parameter values from experimental data, such as the one-step growth. We veri...

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Bibliographic Details
Published in:Journal of theoretical biology 2015-11, Vol.385, p.112-118
Main Authors: de Rioja, V.L., Fort, J., Isern, N.
Format: Article
Language:English
Subjects:
Animals
Bacteriophage T7 - genetics
Bacteriophage T7 - physiology
Biophysics
Diffusion
Escherichia coli - virology
Front propagation
Mathematical model
Models, Biological
Mutation
Reaction–diffusion equations
Virus dynamics
Virus Replication
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Summary:We propose a new reaction–diffusion model with an eclipse time to study the spread of viruses on bacterial populations. This new model is both biologically and physically sound, unlike previous ones. We determine important parameter values from experimental data, such as the one-step growth. We verify the proposed model by comparing theoretical and experimental data of the front propagation speed for several T7 virus strains. •We present a spatial spread model of virus infections.•The virus–host bacteria interaction has an improvement linked to the delay time.•Our model is biologically sound and satisfactorily explains the experimental results.•Some previous models did not consider the diffusive delay yielding too fast speeds.
ISSN:0022-5193
1095-8541
DOI:10.1016/j.jtbi.2015.08.005