A Synthetic Antagonist for the Peroxisome Proliferator-activated Receptor γ Inhibits Adipocyte Differentiation

While searching for natural ligands for the peroxisome proliferator-activated receptor (PPAR) γ, we identified a synthetic compound that binds to this receptor. Bisphenol A diglycidyl ether (BADGE) is a ligand for PPARγ with aKd(app) of 100 μm. This compound has no apparent ability to activate the t...

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Bibliographic Details

Published in:	The Journal of biological chemistry 2000-01, Vol.275 (3), p.1873-1877
Main Authors:	Wright, Harold M., Clish, Clary B., Mikami, Toshiyuki, Hauser, Stefanie, Yanagi, Kazunori, Hiramatsu, Ryuji, Serhan, Charles N., Spiegelman, Bruce M.
Format:	Article
Language:	eng
Subjects:	1-Methyl-3-isobutylxanthine - pharmacology 3T3 Cells Adipocytes - drug effects Animals Benzhydryl Compounds Bisphenol A glycidyl ether Cell Differentiation - drug effects Cell Nucleus - metabolism Chromatography, High Pressure Liquid Dexamethasone - pharmacology Dose-Response Relationship, Drug Epoxy Compounds - chemistry Gas Chromatography-Mass Spectrometry Glucocorticoids - pharmacology Hypoglycemic Agents - pharmacology Insulin - pharmacology Ligands Mice peroxisome proliferator-activated receptor g Phosphodiesterase Inhibitors - pharmacology Protein Binding Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - genetics Rosiglitazone Thiazoles - pharmacology Thiazolidinediones Transcription Factors - antagonists & inhibitors Transcription Factors - genetics Transcription, Genetic - drug effects
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