Synthesis and Glutathione Peroxidase-like activity of N-heterocyclic carbene derived cationic diselenides

Water soluble cationic diselenide derivatives of benzimidazolin-2-selenones and imidazolin-2-selenones have been synthesized. The Glutathione Peroxidase-like (GPx-like) activities of cationic diselenides have been investigated for the first time. The GPx-like activities are found to be quite low as...

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Bibliographic Details
Published in:Tetrahedron 2012-12, Vol.68 (51), p.10561-10566
Main Authors: Manjare, Sudesh T., Singh, Harkesh B., Butcher, Ray J.
Format: Article
Language:English
Subjects:
Carbenes
Cationic
Cationic diselenides
Derivatives
Glutathione
GPx
Hydrogen peroxide
Imidazole
Oxidation reaction
Selenium dioxide
Selenone
Synthesis
Tetrahedrons
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Summary:Water soluble cationic diselenide derivatives of benzimidazolin-2-selenones and imidazolin-2-selenones have been synthesized. The Glutathione Peroxidase-like (GPx-like) activities of cationic diselenides have been investigated for the first time. The GPx-like activities are found to be quite low as compared to the neutral imidazole based diselenide and intramolecularly coordinated diselenides. A mechanism for GPx-like activity has been proposed. The oxidation reactions of N-heterocyclic carbene derived selenones with hydrogen peroxide have been studied. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2012.09.024