Human Herpesvirus 8 and Epstein Barr-Virus in a Cutaneous B-Cell Lymphoma and a Malignant Cell Line Established from the Blood of an AIDS Patient

Human Herpesvirus 8 (HHV-8) has been consistently associated with Primary Effusion Lymphoma (PEL or body-cavity-based lymphoma) but not with other lymphomas. This paper reports on an AIDS patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where HHV-8 and Epstei...

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Bibliographic Details
Published in:Leukemia & lymphoma 1999, Vol.35 (3-4), p.379-387
Main Authors: Morand, Patrice, Buisson, Marlyse, Collandre, Helene, Chanzy, Bruno, Genoulaz, Odile, Bourgeat, Marie-Joseite, Pinel, Nicole, Leclercq, Pascale, Leroux, Dominique, Marechal, Vincent, Fritsch, Laurent, Ruigrok, Rob, Seigneurin, Jean-Marie
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - blood
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - pathology
Acquired Immunodeficiency Syndrome - virology
AIDS/HIV
cell line
Epstein-Barr virus
Herpesvirus 4, Human - isolation & purification
Herpesvirus 8, Human - isolation & purification
human herpesvirus 8
Humans
Lymphoma
Lymphoma - etiology
Lymphoma - virology
Lymphoma, B-Cell - etiology
Lymphoma, B-Cell - virology
Molecular Sequence Data
Skin Neoplasms - etiology
Skin Neoplasms - virology
Tumor Cells, Cultured
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Summary:Human Herpesvirus 8 (HHV-8) has been consistently associated with Primary Effusion Lymphoma (PEL or body-cavity-based lymphoma) but not with other lymphomas. This paper reports on an AIDS patient without obvious malignant effusion in body cavities but with a cutaneous lymphoma where HHV-8 and Epstein-Barr virus (EB V) were detected by PCR and electron microscopy. Both viruses were also detected in all the cells of a malignant cell line (BBG1) established from the patient's peripheral blood mononuclear cells. As in PEL and PEL-derived cell lines, both the tumor and the lines lacked B-antigen expression in immuno-logical studies but were of the same B origin as shown by clonal immunoglobulin gene rearrangements. In contrast to other co-infected cell lines, BBGl and subclones spontaneously expressed the HHV-8 lytic antigens p40, p27, p60 and the EBV transfonning latent antigen EBNA2. These data suggest that the clinical and biological features of HHV-8-and EBV-asso-ciated lymphomas could be wider than has been described to date in PEL particularly with the in vivo presence of circulating malignant dually-infected cells engaged in a spontaneous HBV-8lytic infection.
ISSN:1042-8194
1029-2403
DOI:10.3109/10428199909145743