Up-regulation of the expression of cocaine and amphetamine-regulated transcript peptide by electroacupuncture in the arcuate nucleus of diet-induced obese rats

It was reported that acupuncture or electro-acupuncture (EA) is effective in reducing the body weight for obese patients, although the mechanisms remain obscure. In a previous study, we have found that rats fed with high-fat (HIF) diet developed diet-induced obesity (DIO) with a concomitant decrease...

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Bibliographic Details
Published in:Neuroscience letters 2005-07, Vol.383 (1), p.17-21
Main Authors: Tian, De-Run, Li, Xiao-Dong, Wang, Fei, Niu, Dong-Bin, He, Qi-Hua, Li, Yun-Sheng, Chang, Jaw-Kang, Yang, Jun, Han, Ji-Sheng
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Analysis of Variance
Animals
Arcuate nucleus
Arcuate Nucleus of Hypothalamus - cytology
Arcuate Nucleus of Hypothalamus - drug effects
Arcuate Nucleus of Hypothalamus - metabolism
Arcuate Nucleus of Hypothalamus - radiation effects
Biological and medical sciences
Body weight
Body Weight - drug effects
Body Weight - radiation effects
CART
Cell Count - methods
Diet-induced obesity
Dietary Fats - adverse effects
Dose-Response Relationship, Radiation
Electroacupuncture
Electroacupuncture - methods
Enzyme-Linked Immunosorbent Assay - methods
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - radiation effects
Immunohistochemistry - methods
Male
Medical sciences
Miscellaneous
Nerve Tissue Proteins - metabolism
Obesity - chemically induced
Obesity - therapy
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Rats
Rats, Sprague-Dawley
Restraint, Physical - methods
Time Factors
Vertebrates: nervous system and sense organs
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Summary:It was reported that acupuncture or electro-acupuncture (EA) is effective in reducing the body weight for obese patients, although the mechanisms remain obscure. In a previous study, we have found that rats fed with high-fat (HIF) diet developed diet-induced obesity (DIO) with a concomitant decrease in the hypothalamic content of the cocaine and amphetamine-regulated transcript (CART) peptide, a peptide with anorexiogenic effect. To assess the central effect of EA on DIO rat, we revealed that EA up-regulated the expression of CART peptide in the arcuate nucleus (ARC) of the DIO rats. After feeding with HIF diet for 14 weeks, the DIO rats received EA stimulation three times per week for 4 weeks. The expression of CART peptide in ARC was measured using immunohistochemistry. The plasma ACTH was measured with ELISA. EA caused a reduction of both body weight and energy intake in DIO rats and increased the expression of CART peptide in ARC. The plasma ACTH was increased in response to restraint stress, but EA produced no further increase in ACTH levels. The results suggest that EA can up-regulate the expression of CART peptide to approach normal level, resulting in an inhibition of food intake and a reduction of body weight in DIO rats.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2005.03.039