Association of periodontitis with insulin resistance, β-cell function, and impaired fasting glucose before onset of diabetes

Periodontitis and insulin resistance (IR) show bidirectional relationship. No studies have assessed the associations of periodontitis with IR, impaired β-cell function, and impaired fasting glucose (IFG) in the general population. We investigated these associations in a representative sample of the...

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Bibliographic Details
Published in:Endocrine Journal 2015, Vol.62(11), pp.981-989
Main Authors: Islam, SKM Azizul, Seo, Minchul, Lee, Young-Sil, Moon, Seong-Su
Format: Article
Language:English
Subjects:
Adult
Aged
Blood Glucose - metabolism
Female
Humans
Impaired fasting glucose
Insulin resistance
Insulin Resistance - physiology
Insulin-Secreting Cells - metabolism
Male
Middle Aged
Periodontitis
Periodontitis - metabolism
Prediabetic State - metabolism
Young Adult
β-cell function
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Summary:Periodontitis and insulin resistance (IR) show bidirectional relationship. No studies have assessed the associations of periodontitis with IR, impaired β-cell function, and impaired fasting glucose (IFG) in the general population. We investigated these associations in a representative sample of the Korean population. The subjects were 8,248 males and 10,874 females, who were ≥ 20 years of age and participants in the third, fourth, and fifth Korea National Health and Nutritional Examination Surveys (2008-2010). Periodontitis was defined as community periodontal index (CPI) ≥ code 3 according to World Health Organization criteria. Homeostasis model assessments of IR and β-cell function (HOMA-IR and HOMA-β) were calculated. Participants with periodontitis showed a higher prevalence of diabetes than those without periodontitis. Among subjects without diabetes, after adjustment for confounding factors including age, gender, body mass index, systolic blood pressure, serum total cholesterol, smoking status, alcohol consumption, region, and regular exercise, a comparison of participants with periodontitis vs those without showed a significantly higher prevalence of IFG (28.5% vs. 17.7%, p
ISSN:0918-8959
1348-4540
DOI:10.1507/endocrj.EJ15-0350