EUS-guided drainage of pancreatic fluid collections using a novel lumen-apposing metal stent on an electrocautery-enhanced delivery system: a large retrospective study (with video)

Background and Aims A lumen-apposing, self-expanding metal stent incorporated in an electrocautery-enhanced delivery system for EUS-guided drainage of pancreatic fluid collections (PFCs) recently has become available. The aim of this study was to analyze the safety and clinical effectiveness of this...

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Published in:Gastrointestinal endoscopy 2015-12, Vol.82 (6), p.1039-1046
Main Authors: Rinninella, Emanuele, MD, Kunda, Rastislav, MD, Dollhopf, Markus, MD, Sanchez-Yague, Andres, MD, Will, Uwe, MD, Tarantino, Ilaria, MD, Gornals Soler, Joan, MD, Ullrich, Sebastian, MD, Meining, Alexander, MD, Esteban, Josè Miguel, MD, Enz, Thomas, MD, Vanbiervliet, Geoffroy, MD, Vleggaar, Frank, MD, Attili, Fabia, MD, Larghi, Alberto, MD, PhD
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Drainage - instrumentation
Drainage - methods
Electrocoagulation - instrumentation
Endosonography
Female
Gastroenterology and Hepatology
Humans
Male
Middle Aged
Pancreatic Juice
Pancreatitis - therapy
Retrospective Studies
Self Expandable Metallic Stents
Treatment Outcome
Ultrasonography, Interventional
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Summary:Background and Aims A lumen-apposing, self-expanding metal stent incorporated in an electrocautery-enhanced delivery system for EUS-guided drainage of pancreatic fluid collections (PFCs) recently has become available. The aim of this study was to analyze the safety and clinical effectiveness of this newly developed device in this clinical setting. Methods This was a retrospective analysis of all consecutive patients with PFCs who underwent EUS-guided drainage using the study device in 13 European centers. Results Ninety-three patients with PFCs (80% with complex collections) underwent drainage using the study device. Penetration of the PFC was accomplished directly with the study device in 74.2% of patients, and successful stent placement was accomplished in all but 1 patient, mostly without fluoroscopic assistance. Direct endoscopic necrosectomy (DEN) was carried out in 31 of 52 cases (59.6%) of walled-off necrosis and in 2 of 4 cases (50%) of acute peripancreatic fluid collection. Complete resolution of the PFC was obtained in 86 cases (92.5%), with no recurrence during follow-up. Treatment failure occurred in 6 patients because of persistent infection requiring surgery (n = 3), perforation and massive bleeding caused by the nasocystic drainage catheter (NCDC) (n = 2), and the need for a larger opening to extract large necrotic tissue pieces (n = 1). Major adverse events occurred in 5 patients (perforation and massive bleeding caused by the NCDC in 2 patients, 1 pneumoperitoneum and 1 stent dislodgement during DEN, and 1 postdrainage infection) and were mostly not related to the drainage procedure. Conclusions EUS-guided drainage with the electrocautery-enhanced delivery system is a safe, easy to perform, and a highly effective minimally invasive treatment modality for PFCs.
ISSN:0016-5107
1097-6779
DOI:10.1016/j.gie.2015.04.006