Impact of carotid atherosclerosis loci on cardiovascular events

Abstract Background Genome-wide association studies (GWAS) have identified six single-nucleotide polymorphisms (SNPs) related to carotid intima media thickness (cIMT) or plaque. However, whether these loci relate to other vascular diseases and subsequent vascular events is unclear. Methods and resul...

Full description

Saved in:
Bibliographic Details
Published in:Atherosclerosis 2015-12, Vol.243 (2), p.466-468
Main Authors: Hemerich, Daiane, van der Laan, Sander W, Tragante, Vinicius, den Ruijter, Hester M, de Borst, Gert Jan, Pasterkamp, Gerard, de Bakker, Paul I.W, Asselbergs, Folkert W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Ankle Brachial Index
Aortic Aneurysm, Abdominal - diagnosis
Aortic Aneurysm, Abdominal - genetics
Atherosclerosis
Brain Ischemia - diagnosis
Brain Ischemia - genetics
Cardiovascular
Carotid Arteries - diagnostic imaging
Carotid Arteries - pathology
Carotid Artery Diseases - diagnosis
Carotid Artery Diseases - genetics
Carotid Intima-Media Thickness
Case-Control Studies
Coronary Artery Disease - diagnosis
Coronary Artery Disease - genetics
Female
Genetic Association Studies
Genetic Loci
Genetic Markers
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Odds Ratio
Peripheral Arterial Disease - diagnosis
Peripheral Arterial Disease - genetics
Phenotype
Plaque
Plaque, Atherosclerotic
Polymorphism, Single Nucleotide
Predictive Value of Tests
Proportional Hazards Models
Risk Assessment
Risk Factors
Single-nucleotide polymorphisms
Stroke - diagnosis
Stroke - genetics
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background Genome-wide association studies (GWAS) have identified six single-nucleotide polymorphisms (SNPs) related to carotid intima media thickness (cIMT) or plaque. However, whether these loci relate to other vascular diseases and subsequent vascular events is unclear. Methods and results We tested six SNPs (rs4888378, rs11781551, rs445925, rs6601530, rs17398575 and rs1878406) for association with subclinical atherosclerotic measures (cIMT, plaque presence and ankle-brachial index), as well as ischemic stroke, abdominal aortic aneurysm, peripheral or coronary artery disease (CAD) in the Second Manifestations of ARTerial disease (SMART) cohort. Four SNPs were associated with cIMT and two with plaque (p 
ISSN:0021-9150
1879-1484
DOI:10.1016/j.atherosclerosis.2015.10.017