Incidence of Stroke or Systemic Embolism in Paroxysmal Versus Sustained Atrial Fibrillation: The Fushimi Atrial Fibrillation Registry

BACKGROUND AND PURPOSE—There is controversy on the relationship of the type of atrial fibrillation (AF) to stroke. Although several studies show that patients with paroxysmal AF (PAF) have a stroke risk similar to those with persistent or permanent AF, recent studies suggest that PAF is associated w...

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Bibliographic Details
Published in:Stroke (1970) 2015-12, Vol.46 (12), p.3354-3361
Main Authors: Takabayashi, Kensuke, Hamatani, Yasuhiro, Yamashita, Yugo, Takagi, Daisuke, Unoki, Takashi, Ishii, Mitsuru, Iguchi, Moritake, Masunaga, Nobutoyo, Ogawa, Hisashi, Esato, Masahiro, Chun, Yeong-Hwa, Tsuji, Hikari, Wada, Hiromichi, Hasegawa, Koji, Abe, Mitsuru, Lip, Gregory Y.H, Akao, Masaharu
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atrial Fibrillation - diagnosis
Atrial Fibrillation - epidemiology
Cohort Studies
Embolism - diagnosis
Embolism - epidemiology
Female
Humans
Incidence
Japan - epidemiology
Male
Middle Aged
Prospective Studies
Registries
Risk Factors
Stroke - diagnosis
Stroke - epidemiology
Citations: Items that this one cites
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Summary:BACKGROUND AND PURPOSE—There is controversy on the relationship of the type of atrial fibrillation (AF) to stroke. Although several studies show that patients with paroxysmal AF (PAF) have a stroke risk similar to those with persistent or permanent AF, recent studies suggest that PAF is associated with a lower rate of stroke. Limited data on stroke risk associated with PAF are evident in Asian populations. METHODS—The Registry Study of Atrial Fibrillation Patients in Fushimi-ku (Fushimi AF Registry) is a community-based survey of patients with AF in Fushimi-ku, Kyoto, Japan. Patients were categorized into 2 types of AFPAF or sustained (persistent or permanent) AF. We compared clinical events between PAF (n=1588) and sustained AF (n=1716). RESULTS—Patients with PAF were younger, had less comorbidities, and received oral anticoagulants (OAC) less commonly. A lower risk of stroke/systemic embolism during follow-up period in the patients with PAF was consistently observed (non-OAC usershazard ratio, 0.45; 95% confidence intervals, 0.27–0.75; P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.115.010947