Poor functional immune recovery in aged HIV-1-infected patients following successfully treatment with antiretroviral therapy

Abstract Aging is now a well-recognized characteristic of the HIV-infected population and both AIDS and aging are characterized by a deficiency of the T-cell compartment. The objective of the present study was to evaluate the impact of antiretroviral (ARV) therapy in recovering functional response o...

Full description

Saved in:
Bibliographic Details
Published in:Human immunology 2015-10, Vol.76 (10), p.701-710
Main Authors: Kasahara, Taissa M, Hygino, Joana, Andrade, Regis M, Monteiro, Clarice, Sacramento, Priscila M, Andrade, Arnaldo F.B, Bento, Cleonice A.M
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aging - immunology
Aging - pathology
Allergy and Immunology
Anti-HIV Agents - therapeutic use
Antibodies, Viral - biosynthesis
Antiretroviral therapy
Antiretroviral Therapy, Highly Active
Case-Control Studies
CD4 Lymphocyte Count
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - virology
Elderly
Female
HIV
HIV Infections - drug therapy
HIV Infections - immunology
HIV Infections - pathology
HIV Infections - virology
HIV-1 - immunology
Human immunodeficiency virus
Humans
Immune recovery
Interleukin-10 - biosynthesis
Interleukin-10 - immunology
Interleukin-17 - biosynthesis
Interleukin-17 - immunology
Interleukins - biosynthesis
Interleukins - immunology
Male
Middle Aged
Peptides - pharmacology
Primary Cell Culture
Tetanus toxoid
Tetanus Toxoid - pharmacology
Viral Load - drug effects
Viral Proteins - pharmacology
Virus Replication - drug effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aging is now a well-recognized characteristic of the HIV-infected population and both AIDS and aging are characterized by a deficiency of the T-cell compartment. The objective of the present study was to evaluate the impact of antiretroviral (ARV) therapy in recovering functional response of T cells to both HIV-1-specific ENV peptides (ENV) and tetanus toxoid (TT), in young and aged AIDS patients who responded to ARV therapy by controlling virus replication and elevating CD4+ T cell counts. Here, we observed that proliferative response of T-cells to either HIV-1-specific Env peptides or tetanus toxoid (TT) was significantly lower in older antiretroviral (ARV)-treated patients. With regard to cytokine profile, lower levels of IFN-γ, IL-17 and IL-21, associated with elevated IL-10 release, were produced by Env- or TT-stimulated T-cells from older patients. The IL-10 neutralization by anti-IL-10 mAb did not elevate IFN-γ and IL-21 release in older patients. Finally, even after a booster dose of TT, reduced anti-TT IgG titers were quantified in older AIDS patients and it was related to both lower IL-21 and IFN-γ production and reduced frequency of central memory T-cells. Our results reveal that ARV therapy, despite the adequate recovery of CD4+ T cell counts and suppression of viremia, was less efficient in recovering adequate immune response in older AIDS patients.
ISSN:0198-8859
1879-1166
DOI:10.1016/j.humimm.2015.09.023