Comparative study of the radiobiological effects induced on adherent vs suspended cells by BNCT, neutrons and gamma rays treatments

The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivit...

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Bibliographic Details
Published in:Applied radiation and isotopes 2015-12, Vol.106, p.226-232
Main Authors: Cansolino, L., Clerici, A.M., Zonta, C., Dionigi, P., Mazzini, G., Di Liberto, R., Altieri, S., Ballarini, F., Bortolussi, S., Carante, M.P., Ferrari, M., González, S.J., Postuma, I., Protti, N., Santa Cruz, G.A., Ferrari, C.
Format: Article
Language:English
Subjects:
Animals
BNCT
Boron Neutron Capture Therapy
Cell Adhesion - radiation effects
Cell cycle
Cell Cycle - radiation effects
Cell Line, Tumor
Cell survival
Gamma Rays
Neoplasms - pathology
Neoplasms - radiotherapy
Neutrons
Radiobiological effects
Rats
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Summary:The present work is part of a preclinical in vitro study to assess the efficacy of BNCT applied to liver or lung coloncarcinoma metastases and to limb osteosarcoma. Adherent growing cell lines can be irradiated as adherent to the culture flasks or as cell suspensions, differences in radio-sensitivity of the two modalities of radiation exposure have been investigated. Dose related cell survival and cell cycle perturbation results evidenced that the radiosensitivity of adherent cells is higher than that of the suspended ones.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2015.07.054