Classification of pro-inflammatory status for interleukin-6 affects relative muscle strength in obese elderly women

Background Obesity, defined by an excess amount of body fat or a percent body fat higher than 30 % for women is a complex chronic disorder with multifactorial etiology and is accompanied by chronic low-grade inflammation, which results in elevated pro-inflammatory cytokines. Aims The aim of this stu...

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Bibliographic Details
Published in:Aging clinical and experimental research 2015-12, Vol.27 (6), p.791-797
Main Authors: da Cunha Nascimento, Dahan, de Sousa, Nuno Manuel Frade, de Sousa Neto, Ivo Vieira, Tibana, Ramires Alsamir, de Souza, Vinicius Carolino, Vieira, Denis Cesar Leite, Camarço, Nathalia Ferreira, de Oliveira, Sandra, de Almeida, Jeeser Alves, Navalta, James, Prestes, Jonato
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - methods
Aged
Aging - physiology
Body Composition - immunology
Body fat
Body Mass Index
Chronic Disease
Comorbidity
Female
Geriatrics/Gerontology
Humans
Inflammation - blood
Inflammation - physiopathology
Interleukin-6 - immunology
Lower Extremity - physiopathology
Medicine
Medicine & Public Health
Middle Aged
Muscle strength
Muscle Strength - physiology
Obesity - complications
Obesity - diagnosis
Obesity - immunology
Obesity - physiopathology
Older people
Original Article
Statistics as Topic
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Summary:Background Obesity, defined by an excess amount of body fat or a percent body fat higher than 30 % for women is a complex chronic disorder with multifactorial etiology and is accompanied by chronic low-grade inflammation, which results in elevated pro-inflammatory cytokines. Aims The aim of this study was to compare muscle strength between high and low pro-inflammatory status in obese elderly women and to verify the relationship of IL-6 with muscle strength and fat-free mass. Methods Eighty-nine elderly women (age 69.47 ± 6.07 years; body mass 64.70 ± 12.04 kg; height 1.52 ± 0.06 m; body mass index 27.78 ± 4.75 kg/m 2 ) were divided into two groups: high and low inflammatory status for IL-6. Lower limb muscle strength was tested using bilateral leg extension with the ten repetitions maximum test, IL-6 was measured by ELISA and body composition by dual-energy X-ray absorptiometry. Results Women classified from the high pro-inflammatory status presented lower relative muscle strength ( P  = 0.056) when compared with the low inflammatory status group, with no differences for absolute muscle strength ( P  = 0.18). There was a significant negative correlation of IL-6 with relative muscle strength ( P  = 0.03, R  = −0.22) and a considerable trend toward significance ( P  = 0.06, R  = −0.19) and negative association with fat-free mass ( P  = 0.84, R  = −0.02). Conclusions This study provides insights that a high pro-inflammatory status in sedentary obese elderly women might impair muscle strength and negatively affect fat-free mass. Thus, elderly women classified with high pro-inflammatory status for IL-6 should receive further health care attention to prevent this deleterious condition.
ISSN:1720-8319
1594-0667
1720-8319
DOI:10.1007/s40520-015-0349-9