Antibacterial effect of garlic and omeprazole on Helicobacter pylori

The antibacterial effect of a home-made raw garlic extract and commercial garlic tablets alone and in combination with antibiotics or omeprazole was determined against clinical isolates of Helicobacter pylori. MIC values of raw garlic extract and three types of commercial garlic tablets ranged from...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1999-06, Vol.43 (6), p.837-839
Main Authors: JONKERS, D, VAN DEN BROEK, E, VAN DOOREN, I, THIJS, C, DORANT, E, HAGEMAN, G, STOBBERINGH, E
Format: Article
Language:English
Subjects:
Allium sativum
Anti-Bacterial Agents - pharmacology
Anti-Ulcer Agents - pharmacology
Antibacterial agents
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteriology
Biological and medical sciences
Drug Synergism
Fundamental and applied biological sciences. Psychology
Garlic - chemistry
Helicobacter pylori
Helicobacter pylori - drug effects
Helicobacter pylori - isolation & purification
Humans
Medical sciences
Microbial Sensitivity Tests
Microbiology
Omeprazole - pharmacology
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plants, Medicinal
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Summary:The antibacterial effect of a home-made raw garlic extract and commercial garlic tablets alone and in combination with antibiotics or omeprazole was determined against clinical isolates of Helicobacter pylori. MIC values of raw garlic extract and three types of commercial garlic tablets ranged from 10,000 to 17,500 mg/L. When MIC values of the commercial tablets were based on the allicin content, no differences between the three types were observed. The combination of garlic and omeprazole, studied with killing curves, showed a synergic effect which was concentration dependent. Further clinical evaluation of garlic in combination with the conventional agents for H. pylori treatment seems warranted.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/43.6.837