Effect of prophylactic benzydamine hydrochloride on postoperative sore throat and hoarseness after tracheal intubation using a double-lumen endobronchial tube: a randomized controlled trial

Purpose We evaluated the prophylactic effect of benzydamine hydrochloride (BH) spray on postoperative sore throat and hoarseness secondary to intubation with a double-lumen endobronchial tube (DLT). Methods Ninety-two adult patients undergoing thoracic surgery using DLT intubation were studied. The...

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Bibliographic Details
Published in:Canadian journal of anesthesia 2015-10, Vol.62 (10), p.1097-1103
Main Authors: Chang, Jee-Eun, Min, Seong-Won, Kim, Chong-Soo, Han, Sung-Hee, Kwon, Yong-Suk, Hwang, Jin-Young
Format: Article
Language:English
Subjects:
Adult
Aged
Anesthesiology
Benzydamine - administration & dosage
Cardiology
Clinical trials
Critical Care Medicine
Female
Hoarseness - epidemiology
Hoarseness - etiology
Hoarseness - prevention & control
Humans
Incidence
Information services
Intensive
Intubation
Intubation, Intratracheal - adverse effects
Intubation, Intratracheal - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Pain Measurement
Pain Medicine
Pediatrics
Pharyngitis - epidemiology
Pharyngitis - etiology
Pharyngitis - prevention & control
Pneumology/Respiratory System
Postoperative Complications - epidemiology
Postoperative Complications - etiology
Postoperative Complications - prevention & control
Postoperative Period
Reports of Original Investigations
Severity of Illness Index
Thoracic surgery
Time Factors
Young Adult
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Summary:Purpose We evaluated the prophylactic effect of benzydamine hydrochloride (BH) spray on postoperative sore throat and hoarseness secondary to intubation with a double-lumen endobronchial tube (DLT). Methods Ninety-two adult patients undergoing thoracic surgery using DLT intubation were studied. The DLT cuff and oropharyngeal cavity were sprayed with normal saline (Group S; n = 46) or BH (Group BH; n = 46) prior to intubation. Postoperative sore throat and hoarseness were evaluated at one, six, and 24 hr after surgery. Sore throat was evaluated using a 0-100 mm visual analogue scale (VAS). Hoarseness was defined as a change in voice quality. Results Compared with Group S, postoperative sore throat occurred less frequently in Group BH at one hour (mean difference, 28.3%; 95% confidence interval [CI], 8.7 to 45.1; P = 0.01), at six hours (mean difference, 32.6%; 95% CI, 12.6 to 49.2; P < 0.01), and at 24 hr (mean difference, 28.3%; 95% CI, 9.3 to 44.7; P = 0.01) after surgery. Group BH had lower VAS scores for postoperative sore throat at one hour (mean difference, 12.8; 95% CI, 4.9 to 20.7), at six hours (mean difference, 11.9; 95% CI, 4.8 to 19.1; P < 0.01), and at 24 hr (mean difference, 5.3; 95% CI, 0.9 to 9.7; P = 0.01) after surgery. Hoarseness also occurred less frequently in Group BH at one hour (mean difference, 23.9%; 95% CI, 6.8 to 39.6; P = 0.01), at six hours (mean difference, 23.9%; 95% CI, 7.4 to 39.3; P = 0.01), and at 24 hr (mean difference, 21.7%; 95% CI, 5.5 to 37.0; P = 0.02) after surgery ( P < 0.01). Conclusions Prophylactic application of BH to the DLT cuff and oropharyngeal cavity reduces the incidence and severity of postoperative sore throat and the incidence of hoarseness associated with DLT intubation. The trial was registered at the Clinical Research Information Service (KCT0001068).
ISSN:0832-610X
1496-8975
DOI:10.1007/s12630-015-0432-x