Gastroprotective and Antioxidant Effects of Lobaria pulmonaria and Its Metabolite Rhizonyl Alcohol on Indomethacin-Induced Gastric Ulcer

Two lichen metabolites, rhizonaldehyde (1) and rhizonyl alcohol (2), were isolated from the acetone extract of Lobaria pulmonaria by chromatographic methods, and their chemical structures were determined by UV/VIS, IR, and 1D‐ and 2D‐NMR spectroscopic methods. The gastroprotective and in vivo antiox...

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Bibliographic Details
Published in:Chemistry & biodiversity 2015-11, Vol.12 (11), p.1756-1767
Main Authors: Atalay, Fadime, Odabasoglu, Fehmi, Halici, Mesut, Cakir, Ahmet, Cadirci, Elif, Aslan, Ali, Aydin Berktas, Ozlem, Kazaz, Cavit
Format: Article
Language:English
Subjects:
Alcohol
Alcohols - chemistry
Alcohols - isolation & purification
Alcohols - metabolism
Alcohols - pharmacology
Animals
Anti-Ulcer Agents - chemistry
Anti-Ulcer Agents - isolation & purification
Anti-Ulcer Agents - pharmacology
Antioxidants
Antioxidants - chemistry
Antioxidants - isolation & purification
Antioxidants - pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Female
Gastroprotective effect
Indomethacin - pharmacology
Lichens - chemistry
Lichens - metabolism
Lipid peroxidation
Lipid Peroxidation - drug effects
Lobaria pulmonaria
Metabolites
Molecular Structure
Oxidative Stress - drug effects
Rats
Rats, Wistar
Rhizonaldehyde
Rhizonyl alcohol
Rodents
Stomach Ulcer - chemically induced
Stomach Ulcer - drug therapy
Stomach Ulcer - metabolism
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Summary:Two lichen metabolites, rhizonaldehyde (1) and rhizonyl alcohol (2), were isolated from the acetone extract of Lobaria pulmonaria by chromatographic methods, and their chemical structures were determined by UV/VIS, IR, and 1D‐ and 2D‐NMR spectroscopic methods. The gastroprotective and in vivo antioxidant activities of extracts of L. pulmonaria and its metabolites, 1 and 2, were investigated in indomethacin‐induced ulcer models in rats. The gastric lesions were significantly reduced by acetone, hexane, and CHCl3 extracts, with 75.3–41.5% inhibition. Rhizonyl alcohol (2) significantly reduced the gastric lesions with an inhibition rate of 84.6–42.8%, whereas rhizonaldehyde (1) significantly increased the gastric lesions. Antioxidant parameters and myeloperoxidase activities were also evaluated in the gastric tissues of the rats. Indomethacin caused oxidative stress, which resulted in lipid peroxidation in gastric tissues by decreasing the levels of the antioxidants as compared to healthy rat tissues. In contrast to indomethacin, all extracts and rhizonyl alcohol (2) caused a significant decrease in lipid peroxidation levels and an increase in antioxidant parameters, superoxide dismutase, glutathione peroxidase, and glutathione‐S‐transferase, and reduced glutathione in gastric tissues. The administration of rhizonyl alcohol (2) also resulted in a decrease in gastric myeloperoxidase activity increased by indomethacin. The gastroprotective effect of rhizonyl alcohol (2) can be attributed to its antioxidant properties and its suppressing effect on neutrophil infiltration into gastric tissues.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201400432