Comparison of corneal keratocytes before and after corneal collagen cross-linking in keratoconus patients

Keratoconus is a bilateral and asymmetric corneal ectasia. Cross-linking uses ultra-violate rays to enhance corneal tissue. The purpose of this study was to use in vivo confocal microscopy to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking (CXL) in kera...

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Bibliographic Details
Published in:International ophthalmology 2015-12, Vol.35 (6), p.785-792
Main Authors: Aminifard, Mohammad-Naeim, Khallaghi, Hoda, Mohammadi, Mahdi, Jafarzadeh, Reza
Format: Article
Language:English
Subjects:
Adult
Collagen - metabolism
Corneal Keratocytes - pathology
Corneal Stroma - pathology
Cross-Linking Reagents - therapeutic use
Female
Humans
Keratoconus - drug therapy
Keratoconus - pathology
Male
Medicine
Medicine & Public Health
Microscopy, Confocal
Ophthalmology
Original Paper
Photochemotherapy - methods
Photosensitizing Agents - therapeutic use
Prospective Studies
Refractive Errors - etiology
Riboflavin - therapeutic use
Visual Acuity
Young Adult
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Summary:Keratoconus is a bilateral and asymmetric corneal ectasia. Cross-linking uses ultra-violate rays to enhance corneal tissue. The purpose of this study was to use in vivo confocal microscopy to quantitatively analyze microstructural changes over time, after corneal collagen cross-linking (CXL) in keratoconus patients. In this before-and-after study, a total of 45 keratoconic eyes were selected for cross-linking among patients referred to Al-Zahra ophthalmology clinic during 2013–2014. All patients underwent complete ophthalmologic examinations. Keratocytes and the present of activated keratocytes were calculated preoperatively and at 1, 3, 6, and 12 months postoperatively using confocal microscopy. One year after CXL, best corrected and best uncorrected visual acuity was increased significantly ( p  
ISSN:0165-5701
1573-2630
DOI:10.1007/s10792-015-0041-2