Nutrient intake in neurofibromatosis type 1: A cross-sectional study

Abstract Objectives To evaluate nutrient intake among adult neurofibromatosis type 1 (NF1) patients. Methods A cross-sectional study of 60 NF1 patients (29 men, 31 women) who were ≥18 y old and were evaluated from September 2012 to September 2013 in a neurofibromatosis outpatient reference center. P...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2015-06, Vol.31 (6), p.858-862
Main Authors: de Souza, Marcio Leandro Ribeiro, M.Sc, Jansen, Ann Kristine, Ph.D, Martins, Aline Stangherlin, M.Sc, Rodrigues, Luiz Oswaldo Carneiro, M.D., Ph.D, de Rezende, Nilton Alves, M.D. Ph.D
Format: Article
Language:English
Subjects:
Adult
Copper
Cross-Sectional Studies
Diet
Diet Surveys
Dietary pattern
Energy Intake
Fatty acids
Feeding Behavior
Female
Food
Food intake
Gastroenterology and Hepatology
Humans
Male
Middle Aged
Neurofibromatosis 1
Neurofibromatosis type 1
Nutrient
Nutrition Assessment
Nutritional Requirements
Nutritional status
Phosphorus
Potassium
Studies
Vitamin B
Vitamin C
Vitamin D
Young Adult
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Summary:Abstract Objectives To evaluate nutrient intake among adult neurofibromatosis type 1 (NF1) patients. Methods A cross-sectional study of 60 NF1 patients (29 men, 31 women) who were ≥18 y old and were evaluated from September 2012 to September 2013 in a neurofibromatosis outpatient reference center. Patients underwent nutritional assessment, including anthropometric and dietary data collection. Food intake was evaluated using three, non-consecutive, self-reported 24-h dietary recall surveys, and nutrient intake was analyzed according to the recommendations of the dietary reference intake document. Results Forty-three patients (72%) recorded energy consumption lower than the estimated daily energy requirement (EER). Men (25/29, 86.2%) were more likely to fail to meet their target EER, compared to women (18/31, 58.1%) ( P  = 0.016). Inadequate intake of vitamin D, magnesium, calcium, and pyridoxine was noted between men and women, and all patients consumed excess sodium. NF1 patients did not consume adequate amounts of fiber or vitamins A and C. Excessive consumption of saturated fatty acids and lipids was also observed in both male and female patients. Conclusions In this study, NF1 patients consumed an unhealthy diet that was rich in fats and sodium and lacking in fiber, vitamins, and minerals. Further studies are needed to investigate the role of these dietary and nutritional patterns in the severity of the clinical manifestations of NF1.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2014.12.021