Development of influenza H7N9 virus like particle (VLP) vaccine: Homologous A/Anhui/1/2013 (H7N9) protection and heterologous A/chicken/Jalisco/CPA1/2012 (H7N3) cross-protection in vaccinated mice challenged with H7N9 virus

Highlights • Recombinant A/Anhui/1/2013 (H7N9) HA, NA and avian M1 form virus like particles. • A(H7N9) VLP form enveloped particles containing HA and NA glycoproteins. • A(H7N9) VLP vaccine induced hemagglutinin inhibition (HAI) titers ≥1:64. • A(H7N9) VLP vaccine 100% protective against wild type...

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Bibliographic Details
Published in:Vaccine 2013-09, Vol.31 (40), p.4305-4313
Main Authors: Smith, Gale E, Flyer, David C, Raghunandan, Ramadevi, Liu, Ye, Wei, Ziping, Wu, Yingyun, Kpamegan, Eloi, Courbron, Denise, Fries, Louis F, Glenn, Gregory M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal models
Animals
antibodies
Antibodies, Viral - immunology
Applied microbiology
Avian flu
Baculoviridae
Baculoviridae - genetics
Baculovirus
Biological and medical sciences
Cell Line
chickens
Cloning
Cross Protection - immunology
Fundamental and applied biological sciences. Psychology
H7N9
Hemagglutination Inhibition Tests
Hemagglutinin
hemagglutinins
Hemagglutinins, Viral - genetics
Hemagglutinins, Viral - immunology
human diseases
immune response
Influenza
Influenza A Virus, H7N3 Subtype - immunology
Influenza A Virus, H7N9 Subtype - immunology
Influenza Vaccines - immunology
insects
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Nanoparticles
Neuraminidase - genetics
Neuraminidase - immunology
nucleotide sequences
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Pandemic
Proteins
sialidase
Spodoptera - genetics
Spodoptera - metabolism
Spodoptera frugiperda
Vaccination
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - immunology
Viral Matrix Proteins - genetics
Viral Matrix Proteins - immunology
virion
Virology
Virus like particle
virus-like particle vaccines
viruses
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Summary:Highlights • Recombinant A/Anhui/1/2013 (H7N9) HA, NA and avian M1 form virus like particles. • A(H7N9) VLP form enveloped particles containing HA and NA glycoproteins. • A(H7N9) VLP vaccine induced hemagglutinin inhibition (HAI) titers ≥1:64. • A(H7N9) VLP vaccine 100% protective against wild type A/Anhui/1/2013 (H7N9) influenza challenge. • A(H7N9) VLP vaccine in vivo data support clinical development in man.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.07.043