Successful immunization against a parasitic nematode by vaccination with recombinant proteins

Highlights • A recombinant sub-unit vaccine protected sheep against Teladorsagia circumcincta. • Vaccine consists of a cocktail of immunomodulatory and immunodominant antigens. • Vaccination reduced fecal egg counts by 58–70% and adult worm burdens by 56–75%. • Best reported protection using nematod...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (37), p.4017-4023
Main Authors: Nisbet, Alasdair J, McNeilly, Tom N, Wildblood, Louise A, Morrison, Alison A, Bartley, David J, Bartley, Yvonne, Longhi, Cassandra, McKendrick, Iain J, Palarea-Albaladejo, Javier, Matthews, Jacqueline B
Format: Article
Language:English
Subjects:
Adjuvants
Adjuvants, Immunologic
adults
Allergy and Immunology
Animals
Antigens
Applied microbiology
Bacteriology
Biological and medical sciences
Cloning
E coli
eggs
Feces - parasitology
food security
Fundamental and applied biological sciences. Psychology
gastroenteritis
helminths
human diseases
immunoglobulin A
Infections
larvae
Microbiology
multiple drug resistance
Nematoda
Nematode
Parasites
pathogens
Peptides
Pets
Proteins
recombinant proteins
Ruminantia
Sheep
Sheep - immunology
Sheep Diseases - immunology
Sheep Diseases - parasitology
Sheep Diseases - prevention & control
Strongylida - pathogenicity
Strongylida Infections - immunology
Strongylida Infections - prevention & control
Strongylida Infections - veterinary
Sub-unit vaccine
subunit vaccines
Teladorsagia circumcincta
temperate zones
Treatment Outcome
vaccination
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Synthetic - administration & dosage
Vaccines, Synthetic - immunology
Vaccines, Synthetic - pharmacology
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Summary:Highlights • A recombinant sub-unit vaccine protected sheep against Teladorsagia circumcincta. • Vaccine consists of a cocktail of immunomodulatory and immunodominant antigens. • Vaccination reduced fecal egg counts by 58–70% and adult worm burdens by 56–75%. • Best reported protection using nematode recombinant vaccine in the definitive host.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.05.026