Some Structural-Functional Characteristics of the Dorsolateral Prefrontal Cortex and the Genu of the Corpus Callosum and Auditory Information Processing (P300) in Healthy Subjects and Patients with Juvenile Schizophrenia

The structural-functional characteristics of the dorsolateral prefrontal cortex and genu of the corpus callosum were studied, along with their interaction with electrophysiological markers of selective attention processes in 18 mentally healthy subjects and 22 patients with juvenile schizophrenia at...

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience and behavioral physiology 2014, Vol.44 (1), p.9-15
Main Authors: Lebedeva, I. S., Sidorin, S. V., Akhadov, T. A., Barkhatova, A. N., Kaleda, V. G., Semenova, N. A.
Format: Article
Language:English
Subjects:
Anisotropy
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain research
Cognition & reasoning
Information processing
Investigations
Medical imaging
Neurobiology
Neuroimaging
Neurosciences
Psychopathology
Schizophrenia
Spectrum analysis
Tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The structural-functional characteristics of the dorsolateral prefrontal cortex and genu of the corpus callosum were studied, along with their interaction with electrophysiological markers of selective attention processes in 18 mentally healthy subjects and 22 patients with juvenile schizophrenia at the remission onset stage and in remission. No statistically significant intergroup differences were found in terms of N-acetylaspartate and choline-containing substance levels (assayed by proton magnetic resonance spectroscopy), while fractional anisotropy (measured by diffusion-tensor magnetic resonance tomography) in the genu of the corpus callosum was lower in the patients group. The absence of any statistically significant correlations between neuroimaging characteristics and assessments of the severity of psychopathological disorders, along with occasional correlational interactions with P300 parameters, suggest weak involvement of the study structures in processes determining cognitive impairments in patients with juvenile schizophrenia.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-013-9885-y