Synthetic biology design to display an 18 kDa rotavirus large antigen on a modular virus-like particle

Highlights • Molecular dynamics simulated large antigen modularization on virus-like particle. • Longer flanking linkers provided flexibility for the display of large antigen. • Modular virus-like particles obtained with module titration strategy.

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Bibliographic Details
Published in:Vaccine 2015-11, Vol.33 (44), p.5937-5944
Main Authors: Lua, Linda H.L, Fan, Yuanyuan, Chang, Cindy, Connors, Natalie K, Middelberg, Anton P.J
Format: Article
Language:English
Subjects:
Allergy and Immunology
Antigens, Viral - chemistry
Antigens, Viral - genetics
Genetic Vectors
Molecular Dynamics Simulation
Polyomavirus - genetics
Protein Engineering - methods
Rotavirus - genetics
Rotavirus Vaccines - chemistry
Rotavirus Vaccines - genetics
Vaccines, Virus-Like Particle - chemistry
Vaccines, Virus-Like Particle - genetics
Online Access:Get full text
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Description
Summary:Highlights • Molecular dynamics simulated large antigen modularization on virus-like particle. • Longer flanking linkers provided flexibility for the display of large antigen. • Modular virus-like particles obtained with module titration strategy.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2015.09.017