Predictors of Pathologic Complete Response After Neoadjuvant Treatment for Rectal Cancer: A Multicenter Study

Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to...

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Bibliographic Details
Published in:Clinical colorectal cancer 2015-12, Vol.14 (4), p.291-295
Main Authors: Armstrong, Dawn, Raissouni, Soundouss, Price Hiller, Julie, Mercer, Jamison, Powell, Erin, MacLean, Anthony, Jiang, Maria, Doll, Corinne, Goodwin, Rachel, Batuyong, Eugene, Zhou, Kevin, Monzon, Jose G, Tang, Patricia A, Heng, Daniel Y, Cheung, Winson Y, Vickers, Michael M
Format: Article
Language:English
Subjects:
Canada
Carcinoembryonic Antigen - blood
Carcinoembryonic antigen level
Chemoradiotherapy - methods
Disease-Free Survival
Gastroenterology and Hepatology
Hematology, Oncology and Palliative Medicine
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Middle Aged
Neoadjuvant chemoradiation
Neoadjuvant Therapy - methods
Pathologic response
Predictive factors
Rectal Neoplasms - pathology
Rectal Neoplasms - therapy
Retrospective Studies
Statin
Survival Rate
Treatment Outcome
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Summary:Micro-Abstract Pathologic complete response (pCR) to neoadjuvant chemoradiation for rectal cancer is associated with better long-term outcomes. To assess the rate and predictors of pCR, we performed a retrospective multicentered study. Lower pretreatment carcinoembryonic antigen level, proximity to anal verge, and statin use are predictors of pCR.
ISSN:1533-0028
1938-0674
DOI:10.1016/j.clcc.2015.06.001