Enantioselective Synthesis of Hemiaminals via Pd-Catalyzed C–N Coupling with Chiral Bisphosphine Mono-oxides

A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N...

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Bibliographic Details
Published in:Journal of the American Chemical Society 2015-11, Vol.137 (43), p.13728-13731
Main Authors: Li, Hongming, Belyk, Kevin M, Yin, Jingjun, Chen, Qinghao, Hyde, Alan, Ji, Yining, Oliver, Steven, Tudge, Matthew T, Campeau, Louis-Charles, Campos, Kevin R
Format: Article
Language:English
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Summary:A novel approach to hemiaminal synthesis via palladium-catalyzed C–N coupling with chiral bisphosphine mono-oxides is described. This efficient new method exhibits a broad scope, provides a highly efficient synthesis of HCV drug candidate elbasvir, and has been applied to the synthesis of chiral N,N-acetals.
ISSN:0002-7863
1520-5126
DOI:10.1021/jacs.5b05934