Inflammatory responses to neutral fat and fatty acids in multiple organs in a rat model of fat embolism syndrome

Highlights • Neutral fat increases the ratio of lung-to-body weight. • Neutral fat forms emboli particularly in pulmonary capillaries and not in liver. • Neutral fat and oleic acid markedly increase inflammatory cytokines. • Oleic acid causes a drastic rise in IL-6 levels 15 h after the injection....

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Bibliographic Details
Published in:Forensic science international 2015-09, Vol.254, p.126-132
Main Authors: Takada, Meri, Chiba, Shoetsu, Nagai, Tomonori, Takeshita, Hiroshi, Kanno, Sanae, Ikawa, Toru, Sakamoto, Kana, Sagi, Morihisa, Ichiba, Kazue, Mukai, Toshiji
Format: Article
Language:English
Subjects:
Animals
Body Weight
Bone marrow
Brain - metabolism
Brain - pathology
Capillaries
Capillaries - pathology
Cytokines
Cytokines - genetics
Cytokines - metabolism
Droplets
Edema
Embolism, Fat - pathology
Embolisms
Fat embolism syndrome
Fat embolisms
Fatty acid
Fatty acids
Fatty Acids - administration & dosage
Forensic Pathology
Forensic sciences
Fractures
Funding
Inflammatory cytokine
Injections
Kidney - metabolism
Kidney - pathology
Legal medicine
Lung - metabolism
Lung - pathology
Lungs
Medicine
Models, Animal
Mortality
Myocardium - metabolism
Myocardium - pathology
Neutral fat
Oils & fats
Oleic acid
Organ Size
Organs
Pathology
Permeability
Proteins
Rat
Rats, Wistar
RNA, Messenger - metabolism
Rodents
Subcutaneous Fat - transplantation
Trauma
Tumor necrosis factor-TNF
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Description
Summary:Highlights • Neutral fat increases the ratio of lung-to-body weight. • Neutral fat forms emboli particularly in pulmonary capillaries and not in liver. • Neutral fat and oleic acid markedly increase inflammatory cytokines. • Oleic acid causes a drastic rise in IL-6 levels 15 h after the injection.
ISSN:0379-0738
1872-6283
DOI:10.1016/j.forsciint.2015.07.011