The C. elegans Thermosensory Neuron AFD Responds to Warming

The mechanism of temperature sensation is far less understood than the sensory response to other environmental stimuli such as light, odor, and taste. Thermotaxis behavior in C. elegans requires the ability to discriminate temperature differences as small as ∼0.05°C and to memorize the previously cu...

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Bibliographic Details
Published in:Current biology 2004-07, Vol.14 (14), p.1291-1295
Main Authors: Kimura, Koutarou D, Miyawaki, Atsushi, Matsumoto, Kunihiro, Mori, Ikue
Format: Article
Language:English
Subjects:
Animals
Animals, Genetically Modified
Biological Transport, Active - physiology
Caenorhabditis elegans - physiology
Caenorhabditis elegans Proteins - physiology
Calcium - physiology
Fluorescence
Hot Temperature
Ion Channels - physiology
Mutagenesis, Site-Directed
Neurons - physiology
Plasmids - genetics
Thermosensing - physiology
Transformation, Genetic
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Summary:The mechanism of temperature sensation is far less understood than the sensory response to other environmental stimuli such as light, odor, and taste. Thermotaxis behavior in C. elegans requires the ability to discriminate temperature differences as small as ∼0.05°C and to memorize the previously cultivated temperature [1, 2]. The AFD neuron is the only major thermosensory neuron required for the thermotaxis behavior [3]. Genetic analyses have revealed several signal transduction molecules that are required for the sensation and/or memory of temperature information in the AFD neuron [4–7], but its physiological properties, such as its ability to sense absolute temperature or temperature change, have been unclear. We show here that the AFD neuron responds to warming. Calcium concentration in the cell body of AFD neuron is increased transiently in response to warming, but not to absolute temperature or to cooling. The transient response requires the activity of the TAX-4 cGMP-gated cation channel, which plays an essential role in the function of the AFD neuron [5]. Interestingly, the AFD neuron further responds to step-like warming above a threshold that is set by temperature memory. We suggest that C. elegans provides an ideal model to genetically and physiologically reveal the molecular mechanism for sensation and memory of temperature information.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2004.06.060