Paradoxical Response to Antituberculous Therapy in Infliximab-Treated Patients with Disseminated Tuberculosis

Six of 284 patients treated with infliximab developed active tuberculosis. Four (67%) of these patients had a paradoxical response to antituberculous therapy. Physicians should be aware of the increased risk of a paradoxical response in this population and should consider the use of corticosteroids...

Full description

Saved in:
Bibliographic Details
Published in:Clinical infectious diseases 2005-03, Vol.40 (5), p.756-759
Main Authors: Garcia Vidal, Carolina, Rodríguez Fernández, Serena, Martínez Lacasa, Javier, Salavert, Miquel, Vidal, Rafael, Rodríguez Carballeira, Mónica, Garau, Javier
Format: Article
Language:English
Subjects:
Adult
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
Antitubercular Agents - adverse effects
Antitubercular Agents - therapeutic use
Antituberculars
Arthritis, Rheumatoid - drug therapy
Bacterial diseases
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Brief Reports
Crohn Disease - drug therapy
Drug therapy
Female
Fever
Granuloma
Human bacterial diseases
Humans
Immunomodulators
Immunosuppressive Agents - adverse effects
Immunosuppressive Agents - therapeutic use
Infectious diseases
Infliximab
Lymph node tuberculosis
Lymph nodes
Lymphatic system
Male
Medical diagnosis
Medical sciences
Middle Aged
Miliary tuberculosis
Mycobacterium tuberculosis
Osteoarticular tuberculosis
Pharmacology. Drug treatments
Pleural tuberculosis
Pulmonary tuberculosis
Retrospective Studies
Side effects
Spondylitis, Ankylosing - drug therapy
Tuberculosis
Tuberculosis and atypical mycobacterial infections
Tuberculosis, Pulmonary - drug therapy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Six of 284 patients treated with infliximab developed active tuberculosis. Four (67%) of these patients had a paradoxical response to antituberculous therapy. Physicians should be aware of the increased risk of a paradoxical response in this population and should consider the use of corticosteroids when a paradoxical reaction is suspected.
ISSN:1058-4838
1537-6591
DOI:10.1086/427941