Polyketides from Mantis-Associated Fungus Daldinia eschscholzii IFB-TL01

Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4–8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytoto...

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Bibliographic Details
Published in:Chemistry & biodiversity 2015-09, Vol.12 (9), p.1349-1355
Main Authors: Wang, Gang, Fan, Jing-Yang, Zhang, Wen-Jing, Hua, Cheng-Pin, Chen, Chao-Jun, Yan, Wei, Ge, Hui-Ming, Jiao, Rui-Hua, Tan, Ren-Xiang
Format: Article
Language:English
Subjects:
Crystallography, X-Ray
Cytotoxic activity
Daldinia
Daldinia eschscholzii
Magnetic Resonance Spectroscopy
Models, Molecular
Polyketides
Polyketides - analysis
Radical coupling
Xylariales - chemistry
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Summary:Three new polyketides, named daldinone F (1), nodulisporin G (2), and dalmanol C (3), together with five known compounds, 4–8, were isolated from cultures of Daldinia eschscholzii. The structures of the new compounds were elucidated by extensive NMR and MS analyses. Compound 1 showed moderate cytotoxic activity against SW480 cancer cells with an IC50 value of 9.59 μM, and its absolute configuration was determined by single crystal X‐ray diffraction.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201400414