Evolution of bacterial transcription factors: how proteins take on new tasks, but do not always stop doing the old ones

Highlights • We suggest a pathway whereby bacterial transcription factors evolved from nucleoid-associated proteins whose original primary role was likely to organise and compact bacterial chromosomes. • This posit can explain many of the properties of the Escherichia coli cyclic AMP receptor protei...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 2015-08, Vol.23 (8), p.463-467
Main Authors: Visweswariah, Sandhya S, Busby, Stephen J.W
Format: Article
Language:English
Subjects:
Bacteria
bacterial gene regulation
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Computational Biology
Evolution, Molecular
Genome, Bacterial
High-Throughput Nucleotide Sequencing
Internal Medicine
Models, Biological
Models, Molecular
nucleoid associated proteins
transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:Highlights • We suggest a pathway whereby bacterial transcription factors evolved from nucleoid-associated proteins whose original primary role was likely to organise and compact bacterial chromosomes. • This posit can explain many of the properties of the Escherichia coli cyclic AMP receptor protein and related proteins.
ISSN:0966-842X
1878-4380
DOI:10.1016/j.tim.2015.04.009