Expression of ezrin in oral squamous cell carcinoma: Prognostic impact and clinicopathological correlations

Abstract Introduction There have been few investigations into the effects of ezrin expression in oral squamous cell carcinoma (OSCC). The aim of this study was to analyze the influence of ezrin expression on the prognosis of patients with OSCC. Materials and methods Eighty patients were included in...

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Published in:Journal of cranio-maxillo-facial surgery 2015-11, Vol.43 (9), p.1899-1905
Main Authors: Safi, Ali-Farid, Nickenig, Hans-Joachim, Rothamel, Daniel, Zirk, Matthias, Thiele, Oliver, Grandoch, Andrea, Scheer, Martin, Zinser, Max, Zöller, Joachim, Drebber, Uta, Kreppel, Matthias
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomarker
Biomarkers, Tumor - metabolism
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - mortality
Carcinoma, Squamous Cell - pathology
Cell Membrane - metabolism
Cytoplasm - metabolism
Cytoskeletal Proteins - metabolism
Dentistry
ERM proteins
Ezrin
Female
Humans
Immunohistochemistry
Male
Middle Aged
Mouth Neoplasms - metabolism
Mouth Neoplasms - mortality
Mouth Neoplasms - pathology
Oral cancer
Prognosis
Retrospective Studies
Surgery
Survival Rate
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Summary:Abstract Introduction There have been few investigations into the effects of ezrin expression in oral squamous cell carcinoma (OSCC). The aim of this study was to analyze the influence of ezrin expression on the prognosis of patients with OSCC. Materials and methods Eighty patients were included in the retrospective study. Expression and localization of ezrin were evaluated using immunohistochemistry. Associations were identified using χ ² tests. Prognostic factors were identified by univariate and multivariate analysis. Results Seventy-six (95%) patients showed ezrin expression. Ezrin expression had a significant impact on overall survival (OS) ( p  
ISSN:1010-5182
1878-4119
DOI:10.1016/j.jcms.2015.08.011