Nongenomic effects of ecdysteroids

The classical mode of action of ecdysteroids (ES) is the receptor-mediated control of gene activity, influencing transcription, and, subsequently, protein synthesis. Most of these actions occur after a lag phase of 10 min or more, usually after several hours. During the last three decades evidence h...

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Bibliographic Details
Published in:Archives of insect biochemistry and physiology 1999, Vol.41 (2), p.89-98
Main Author: Tomaschko, K.H
Format: Article
Language:English
Subjects:
Adenoviridae
adenylate cyclase
allelochemicals
ecdysteroids
gamma-aminobutyric acid
genomic effects
hormonal regulation
ion transport
kinases
literature reviews
mechanism of action
membrane proteins
neurophysiology
nongenomic effects
pheromones
phosphorylation
receptors
uptake
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Summary:The classical mode of action of ecdysteroids (ES) is the receptor-mediated control of gene activity, influencing transcription, and, subsequently, protein synthesis. Most of these actions occur after a lag phase of 10 min or more, usually after several hours. During the last three decades evidence has accumulated that ES also operate independently of genomic action. The nongenomic effects have short latencies, sometimes in the range of a few seconds. This renders possible their semiochemical effects as pheromones and feeding deterrents. The favoured target sites of nongenomic ES effects are presumably plasma membrane associated proteins. ES interact with Na+-K+ATPase, carrier proteins, adenylyl cyclase, GABAA receptor channels, Na+-H+ exchangers, and K+ channels, having impact on ES transport, electrolyte transport (Na+, K+, H+, Ca++, Cl-) or on second messengers (cAMP, Ca++). A new concept of ES action includes both genomic and nongenomic pathways. Furthermore, it seems as if ES can act by both mechanisms simultaneously, modulating their own genomic effects by nongenomic actions.
ISSN:0739-4462
1520-6327
DOI:10.1002/(SICI)1520-6327(1999)41:2<89::AID-ARCH5>3.0.CO;2-1