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Intimate association of visceral obesity with non-alcoholic fatty liver disease in healthy Asians: A case-control study
Background and Aim To identify factors associated with non‐alcoholic fatty liver disease (NAFLD) in healthy Asian subjects. Methods A propensity score‐matched case‐control study was designed. To investigate the effects of demographic and clinical factors on the presence of NAFLD, a baseline‐category...
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Published in: | Journal of gastroenterology and hepatology 2015-11, Vol.30 (11), p.1666-1672 |
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Main Authors: | , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Background and Aim
To identify factors associated with non‐alcoholic fatty liver disease (NAFLD) in healthy Asian subjects.
Methods
A propensity score‐matched case‐control study was designed. To investigate the effects of demographic and clinical factors on the presence of NAFLD, a baseline‐category logit model was used. Potential living liver donors with no hepatic steatosis ( 33%: n = 116, group 3) hepatic steatosis were defined as cases. Age and gender were matched between cases and controls, which resulted in 83 matched subjects in each of the three groups. The area of abdominal (visceral and subcutaneous) fat was directly measured in all subjects by unenhanced computed tomography.
Results
Serum aspartate aminotransferase, alanine aminotransferase (ALT), gamma‐glutamyltranspeptidase, total cholesterol and triglyceride levels, and visceral fat amount were directly correlated with the grade of hepatic steatosis, and high‐density lipoprotein cholesterol levels were inversely correlated with it (all P values |
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ISSN: | 0815-9319 1440-1746 |
DOI: | 10.1111/jgh.12996 |