Effects of Hypoxic Postconditioning on the Expression of Antiapoptotic Protein Bcl-2 and Neurotrophin BDNF in Hippocampal Field CA1 in Rats Subjected to Severe Hypoxia

A quantitative immunohistochemical method was used to study the expression of antiapoptotic protein Bcl-2 and neurotrophin BDNF in hippocampal field CA1 in rats subjected to severe hypoxia (SH), the harmful consequences of which were compensated by three subsequent sessions of postconditioning (Post...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2015-05, Vol.45 (4), p.367-370
Main Authors: Vetrovoi, O. V., Rybnikova, E. A., Glushchenko, T. S., Samoilov, M. O.
Format: Article
Language:English
Subjects:
Animals
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain
Brain-derived neurotrophic factor
Hypoxia
Ischemia
Laboratories
Neurobiology
Neurosciences
Physiology
Proteins
Rehabilitation
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Summary:A quantitative immunohistochemical method was used to study the expression of antiapoptotic protein Bcl-2 and neurotrophin BDNF in hippocampal field CA1 in rats subjected to severe hypoxia (SH), the harmful consequences of which were compensated by three subsequent sessions of postconditioning (PostC) with moderate hypobaric hypoxia (360 mmHg, 2 h, three times with 24-h intervals). Decreases in the expression of these proteins were seen in the hippocampus of rats after SH. Hypoxic PostC, which improves structural-functional rehabilitation after severe hypoxia, increased Bcl-2 and BDNF expression in neurons in hippocampal field CA1 in rats subjected to SH. The results provided evidence of the involvement of Bcl-2 and BDNF in the processes of adaptation to SH and compensation of its damaging effects.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-015-0083-y