Rapid acquisition of helium-3 and proton three-dimensional image sets of the human lung in a single breath-hold using compressed sensing

Purpose To develop and validate a method for acquiring helium‐3 (3He) and proton (1H) three‐dimensional (3D) image sets of the human lung with isotropic spatial resolution within a 10‐s breath‐hold by using compressed sensing (CS) acceleration, and to assess the fidelity of undersampled images compa...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2015-10, Vol.74 (4), p.1110-1115
Main Authors: Qing, Kun, Altes, Talissa A., Tustison, Nicholas J., Feng, Xue, Chen, Xiao, Mata, Jaime F., Miller, G. Wilson, de Lange, Eduard E., Tobias, William A., Cates Jr, Gordon D., Brookeman, James R., Mugler III, John P.
Format: Article
Language:English
Subjects:
Adult
Breath Holding
compressed sensing
Cystic Fibrosis
Female
Helium - administration & dosage
Helium - chemistry
Humans
hyperpolarized gas
Imaging, Three-Dimensional - methods
Lung - physiology
Magnetic Resonance Imaging - methods
Male
Protons
pulmonary imaging
Young Adult
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Summary:Purpose To develop and validate a method for acquiring helium‐3 (3He) and proton (1H) three‐dimensional (3D) image sets of the human lung with isotropic spatial resolution within a 10‐s breath‐hold by using compressed sensing (CS) acceleration, and to assess the fidelity of undersampled images compared with fully sampled images. Methods The undersampling scheme for CS acceleration was optimized and tested using 3He ventilation data. Rapid 3D acquisition of both 3He and 1H data during one breath‐hold was then implemented, based on a balanced steady‐state free‐precession pulse sequence, by random undersampling of k‐space with reconstruction by means of minimizing the L1 norm and total variance. CS‐reconstruction fidelity was evaluated quantitatively by comparing fully sampled and retrospectively undersampled image sets. Results Helium‐3 and 1H 3D image sets of the lung with isotropic 3.9‐mm resolution were acquired during a single breath‐hold in 12 s and 8 s using acceleration factors of 2 and 3, respectively. Comparison of fully sampled and retrospectively undersampled 3He and 1H images yielded mean absolute errors 0.9. Conclusion By randomly undersampling k‐space and using CS reconstruction, high‐quality 3He and 1H 3D image sets with isotropic 3.9‐mm resolution can be acquired within an 8‐s breath‐hold. Magn Reson Med 74:1110–1115, 2015. © 2014 Wiley Periodicals, Inc.
ISSN:0740-3194
1522-2594
DOI:10.1002/mrm.25499