Chronic stress associated with hypercaloric diet changes the hippocampal BDNF levels in male Wistar rats

Highlights • Evaluated the effect of obesity and stress on brain-derived neurotrophic factor (BDNF) levels. • Stress decreases BDNF hippocampus levels. • Stress induces depression-like behavior. • Obesity decreases BDNF hypothalamus levels.

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Bibliographic Details
Published in:Neuropeptides (Edinburgh) 2015-06, Vol.51, p.75-81
Main Authors: Macedo, I.C, Rozisky, J.R, Oliveira, C, Oliveira, C.M, Laste, G, Nonose, Y, Santos, V.S, Marques, P.R, Ribeiro, M.F.M, Caumo, W, Torres, I.L.S
Format: Article
Language:English
Subjects:
Advanced Basic Science
Anhedonia
Animals
BDNF
Behavior, Animal - physiology
Brain-Derived Neurotrophic Factor - metabolism
Chronic stress
Diet
Endocrinology & Metabolism
Energy Intake - physiology
Hippocampus
Hippocampus - metabolism
Hypothalamo-Hypophyseal System - metabolism
Hypothalamus
Male
Obesity
Obesity - metabolism
Pituitary-Adrenal System - metabolism
Rats
Rats, Wistar
Stress, Physiological - physiology
Stress, Psychological - metabolism
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Summary:Highlights • Evaluated the effect of obesity and stress on brain-derived neurotrophic factor (BDNF) levels. • Stress decreases BDNF hippocampus levels. • Stress induces depression-like behavior. • Obesity decreases BDNF hypothalamus levels.
ISSN:0143-4179
1532-2785
DOI:10.1016/j.npep.2015.01.002