A Systematic Review of the Effectiveness of Intravenous Tranexamic Acid Administration in Managing Perioperative Blood Loss in Patients Undergoing Spine Surgery

This systematic review aimed to identify the effectiveness of intravenous tranexamic acid (TXA) administration in managing perioperative blood loss in patients undergoing spine surgery. The study design was a systematic review and meta-analysis. Quantitative articles were pooled in a statistical met...

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Bibliographic Details
Published in:Journal of perianesthesia nursing 2014-12, Vol.29 (6), p.459-465
Main Authors: Badeaux, Jennifer, Hawley, Diane
Format: Article
Language:English
Subjects:
blood loss
Blood Loss, Surgical
Humans
Infusions, Intravenous
intraoperative blood loss
Nursing
Orthopedic Procedures - adverse effects
perioperative blood loss
postoperative blood loss
Spine - surgery
spine surgery or diskectomy or laminectomy or spinal fusion
surgical blood loss
Tranexamic Acid - administration & dosage
tranexamic acid or tranexamic
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Summary:This systematic review aimed to identify the effectiveness of intravenous tranexamic acid (TXA) administration in managing perioperative blood loss in patients undergoing spine surgery. The study design was a systematic review and meta-analysis. Quantitative articles were pooled in a statistical meta-analysis using the Joanna Briggs Institute Meta-Analysis of Statistical Assessment and Review Instrument. Twelve studies totaling 934 participants carried out between 1960 and 2013 were included in the review. Intraoperative blood loss showed statistically significant (P 
ISSN:1089-9472
1532-8473
DOI:10.1016/j.jopan.2014.06.003