POZylation: a new approach to enhance nanoparticle diffusion through mucosal barriers

The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate into, and permeate through, biological membranes to facilitate drug delivery and improve the bioavailability of active pharmaceutical ingredien...

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Bibliographic Details
Published in:Nanoscale 2015-08, Vol.7 (32), p.13671-13679
Main Authors: Mansfield, Edward D H, Sillence, Katy, Hole, Patrick, Williams, Adrian C, Khutoryanskiy, Vitaliy V
Format: Article
Language:English
Subjects:
Animals
Diffusion
Dispersions
Drug delivery systems
Drug Delivery Systems - methods
Gastric Mucins - chemistry
Gastric Mucins - metabolism
Glycols
Nanomedicine - methods
Nanoparticles
Nanoparticles - chemistry
Nanostructure
Pharmaceuticals
Polyamines - chemistry
Polyethylene Glycols - chemistry
Silicon Dioxide
Swine
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Summary:The increasing use of nanoparticles in the pharmaceutical industry is generating concomitant interest in developing nanomaterials that can rapidly penetrate into, and permeate through, biological membranes to facilitate drug delivery and improve the bioavailability of active pharmaceutical ingredients. Here, we demonstrate that the permeation of thiolated silica nanoparticles through porcine gastric mucosa can be significantly enhanced by their functionalization with either 5 kDa poly(2-ethyl-2-oxazoline) or poly(ethylene glycol). Nanoparticle diffusion was assessed using two independent techniques; Nanoparticle Tracking Analysis, and fluorescence microscopy. Our results show that poly(2-ethyl-2-oxazoline) and poly(ethylene glycol) have comparable abilities to enhance diffusion of silica nanoparticles in mucin dispersions and through the gastric mucosa. These findings provide a new strategy in the design of nanomedicines, by surface modification or nanoparticle core construction, for enhanced transmucosal drug delivery.
ISSN:2040-3364
2040-3372
DOI:10.1039/c5nr03178h