Peripheral blood eosinophils and other non‐invasive biomarkers can monitor treatment response in eosinophilic oesophagitis

Summary Background Monitoring of the treatment response in eosinophilic oesophagitis (EoE) requires structured endoscopical and histological examination of the oesophagus. Less invasive methods would be highly desirable. Aim To evaluate the utility of several EoE‐associated blood and serum markers i...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2015-11, Vol.42 (9), p.1122-1130
Main Authors: Schlag, C., Miehlke, S., Heiseke, A., Brockow, K., Krug, A., Arnim, U., Straumann, A., Vieth, M., Bussmann, C., Mueller, R., Greinwald, R., Bajbouj, M.
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Budesonide - therapeutic use
Chemokines, CC - blood
Double-Blind Method
Drug Monitoring
Eosinophil Cationic Protein - blood
Eosinophilic Esophagitis - blood
Eosinophilic Esophagitis - diagnosis
Eosinophilic Esophagitis - drug therapy
Eosinophils
Female
Glucocorticoids - therapeutic use
Humans
Leukocyte Count
Male
Middle Aged
Remission Induction
ROC Curve
Tryptases - blood
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Summary:Summary Background Monitoring of the treatment response in eosinophilic oesophagitis (EoE) requires structured endoscopical and histological examination of the oesophagus. Less invasive methods would be highly desirable. Aim To evaluate the utility of several EoE‐associated blood and serum markers in order to non‐invasively monitor the response to treatment with swallowed topical corticosteroids in adult EoE patients. Methods In a randomised, controlled double‐blind trial blood samples of EoE patients (n = 69) were collected at baseline and after 14 days of treatment with budesonide (n = 51) or placebo (n = 18) respectively. Absolute blood eosinophil count (AEC) as well as serum levels of CCL‐17, CCL‐18, CCL‐26, eosinophil‐cationic‐protein (ECP) and mast cell tryptase (MCT) were determined and correlated with oesophageal eosinophil density and with symptom and endoscopy scores. Results Histological remission, defined as mean number of
ISSN:0269-2813
1365-2036
DOI:10.1111/apt.13386