Some Nuts Are Tougher to Crack than Others

In this issue of Immunity, Oestreich et al. (2006) show that, during V(D)J recombination, RSSs may have distinct accessibility requirements. Some rely on an enhancer-intrinsic, general chromatin opening function, whereas others require enhancer-promoter interactions that direct local chromatin remod...

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2006-04, Vol.24 (4), p.361-363
Main Authors: Krangel, Michael S., Carabana, Juan, Abarrategui, Iratxe
Format: Article
Language:English
Subjects:
Animals
Antibody Diversity - genetics
Chromatin
Chromosomes
Enhancer Elements, Genetic - immunology
Gene Expression Regulation - immunology
Gene Rearrangement, B-Lymphocyte
Gene Rearrangement, T-Lymphocyte
Genes
Genes, Immunoglobulin
Genes, T-Cell Receptor - genetics
Genomics
Humans
Somatic Hypermutation, Immunoglobulin - genetics
T cell receptors
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Summary:In this issue of Immunity, Oestreich et al. (2006) show that, during V(D)J recombination, RSSs may have distinct accessibility requirements. Some rely on an enhancer-intrinsic, general chromatin opening function, whereas others require enhancer-promoter interactions that direct local chromatin remodeling.
ISSN:1074-7613
1097-4180
DOI:10.1016/j.immuni.2006.04.002